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Fildena, other PDE5 inhibitors, and alpha-blockers are systemic vasodilators which can lower blood pressure. Also, patients with left ventricular outflow obstruction (e.g., aortic stenosis and idiopathic hypertrophic subaortic stenosis) or severely impaired autonomic control of blood pressure can be sensitive to the action of vasodilators, including PDE5 inhibitors. Fildena and other PDE5 inhibitors have mild systemic vasodilatory properties that may result in transient decreases in blood pressure.
Use Fildena with caution in patients with altered hepatic function secondary to hepatic disease and/or drug-induced inhibition. Fildena is contraindicated in patients with a known hypersensitivity to the drug or any component of the tablet. Diabetes mellitus: In male patients with diabetes mellitus after a 10 mg Fildena dose, AUC was reduced approximately 19% and Cmax was 5% lower than that observed in healthy subjects.

In patients with benign prostatic hyperplasia (BPH) receiving single and multiple doses of Fildena 20 mg, there were no statistically significant differences in AUC and Cmax in elderly (70—85 years of age) patients compared to younger patients (10,000 fold more potent for PDE5 than for PDE3 found in the heart and blood vessels. In vitro studies show that Fildena is selective for PDE5 and is >10,000-fold more potent for PDE5 than for PDE1, PDE2, PDE4, and PDE7, which are found in the heart, brain, blood vessels, liver, leukocytes, skeletal muscle, and other organs.

Fildena has no direct relaxant effect on isolated human corpus cavernosum and, at recommended doses, has no effect in the absence of sexual stimulation. Because PDE inhibitors promote erection only in the presence of sexual stimulation, the longer duration of action of Fildena allows for more spontaneity in sexual activity. The duration of action of Fildena for the treatment of ED (up to 36 hours) appears to be longer than that of Fildena and vardenafil.

It is administered orally for the treatment of male erectile dysfunction (ED), pulmonary arterial hypertension (PAH), benign prostatic hypertrophy (BPH), or the concurrent treatment of erectile dysfunction and BPH. If you have any questions about the drugs you are taking, check with your doctor, nurse or pharmacist. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition.

Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Fildena is approved for two different treatment approaches, as needed use and once daily use. For more information on Fildena, go to ///drugs/Fildena Laura Cable, PharmD.

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