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The recommended starting dose of Cenforce is 50 mg, although if side effects are experienced then a lower dose should be used. If you have sex more than twice a week you may find that a different medication, Cenforce daily, suits your needs better than Cenforce. If you find that the dosage you are on is too weak, ask your prescribing doctor whether you can increase it. If you do not have any medical conditions and aren't taking any other medications, it is likely that you can increase your dosage from 50mg to 100mg.
Cenforce 25mg tablets contain the lowest available dosage. 62 As of 2016 branded pills cost about 50 times more than generic ones. After oral dosing of Cenforce 100 AUC and Cmax increase in proportion with dose over the recommended dose range (25-100 mg).

In clinical trials Cenforce 100 was administered to more than 8000 patients aged 19-87. In a small size placebo-controlled study of patients with documented early age-related macular degeneration (n=9), Cenforce 100 (single dose, 100 mg) demonstrated no significant changes in the visual tests conducted (visual acuity, Amsler grid, colour discrimination simulated traffic light, Humphrey perimeter and photostress). Single oral doses of Cenforce 100 up to 100 mg in healthy volunteers produced no clinically relevant effects on ECG.

These decreases in blood pressure are consistent with the vasodilatory effects of Cenforce 100, probably due to increased cGMP levels in vascular smooth muscle. Cenforce 100 causes mild and transient decreases in blood pressure which, in the majority of cases, do not translate into clinical effects. Therefore sexual stimulation is required in order for Cenforce 100 to produce its intended beneficial pharmacological effects.

The physiological mechanism responsible for erection of the penis involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. Cenforce 100 is an oral therapy for erectile dysfunction. In a specific interaction study, where Cenforce 100 (100 mg) was co-administered with amlodipine in hypertensive patients, there was an additional reduction on supine systolic blood pressure of 8 mmHg.

Cenforce 100 (50 mg) did not potentiate the hypotensive effects of alcohol in healthy volunteers with mean maximum blood alcohol levels of 80 mg/dl. In a study of healthy male volunteers, co-administration of the endothelin antagonist, bosentan, (an inducer of CYP3A4 moderate, CYP2C9 and possibly of CYP2C19) at steady state (125 mg twice a day) with Cenforce 100 at steady state (80 mg three times a day) resulted in 62.6% and 55.4% decrease in Cenforce 100 AUC and Cmax, respectively. Co-administration of the HIV protease inhibitor saquinavir, a CYP3A4 inhibitor, at steady state (1200 mg three times a day) with Cenforce 100 (100 mg single dose) resulted in a 140% increase in Cenforce 100 Cmax and a 210% increase in Cenforce 100 AUC.

Based on these pharmacokinetic results co-administration of Cenforce 100 with ritonavir is not advised (see section 4.4) and in any event the maximum dose of Cenforce 100 should under no circumstances exceed 25 mg within 48 hours. In order to minimise the potential for developing postural hypotension, patients should be hemodynamically stable on alpha-blocker therapy prior to initiating Cenforce 100 treatment.
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